pK Parameters | Gerbil (s.c.) | Rat (s.c.) |
---|---|---|
Dose (mg/kg) | 24 | 100 |
t1/2 hr | 0.43 | 4.7 |
Elimination rate constant, k10 (hr) | 1.61 | 0.15 |
Absorption rate constant (hr) | 21.4 | 0.42 |
V/f (liters/kg−1)2-a | 2.1 | 2.7 |
Tmax | 7.8 min | 3.8 hr |
Cmax(μg/ml) | 9.3 | 20.2 |
AUC (μg/hr/ml) | 7.1 | 241 |
↵2-a V/f; V = volume of distribution; f = fraction absorbed (assumed to be unity).