Influence of dosing time on SN-38 pharmacokinetic parameters after CPT-11 (100 mg/kg i.p.) injection at 1700 or 0500 hr
| Time after Drug Injection | Time of Drug Injection | Statistical Significance | |
|---|---|---|---|
| 1700 hr | 0500 hr | ||
| AUC (μg · hr/ml) | 7.91 ± 0.40 | 8.10 ± 0.28 | NS |
| MRT (hr) | 5.79 ± 0.18 | 6.88 ± 0.30 | P < .05 |
| VRT (hr2) | 24.66 ± 2.78 | 46.82 ± 7.35 | P < .05 |
Each value is the mean with S.E. of six observations.