Warfarin was also able to increase the potency of Merz glycineBantagonists which suggests moderate binding to plasma albumins
| ED50 | + Warfarin (50 mg/kg) ED50 | |
|---|---|---|
| mg/kg | mg/kg | |
| MRZ 2/502 | 47.6 (22.7–101.5) | 11.3 (9.6–13.3) |
| MRZ 2/514 | 20.2 (8.4–48.7) | 11.8 (8.1–17.0) |
| MRZ 2/516 | 16.6 (10.6–24.2) | 13.2 (7.7–22.8) |
| MRZ 2/576 | 7.7 (6.0–9.8) | 3.2 (1.4–7.2) |
Warfarin (50 mg/kg i.p.) 30 min before administration of the tested agents increased their potency against MES-induced seizures.