Table 1

Effect of L-745,870 on prepulse inhibition of acoustic startle responding in the rat

Dose	Startle Amplitude		% PPI
Dose	P	70 db + P	75 db + P	80 db + P	70 db	75 db	80 db
mg/kg
0	356 ± 56	250 ± 29^*	188 ± 26^*	142 ± 20^*	24 ± 6	43 ± 7	56 ± 5
0.001	376 ± 42	275 ± 31^*	207 ± 27^*	164 ± 20^*	23 ± 8	43 ± 5	54 ± 5
0.01	412 ± 68	319 ± 59^*	231 ± 46^*	174 ± 34^*	23 ± 4	44 ± 5	56 ± 6
0.1	473 ± 54	362 ± 47^*	255 ± 38^*	181 ± 19^*	22 ± 6	46 ± 5	59 ± 4
1	309 ± 39	252 ± 32	197 ± 29^*	134 ± 18^*	17 ± 4	37 ± 3	54 ± 4

Animals were dosed orally with L-745,870 or vehicle 30 min before testing. Results are expressed as the mean startle amplitude ± S.E.M. to 12 repetitions of either a 40-msec, 120-db tone [pulse (P)] or the same pulse preceded 100 msec by either a 70-, 75- or 80-db prepulse. Data for individual animals were also expressed as a % inhibition (i.e., %PPI = [pulse − (prepulse + pulse)]/pulse × 100) and shown as the mean ± S.E.M. % PPI at each dose (n = 11–12/group). Data for startle amplitudes were analyzed by simple main effects analysis of variance to compare pulse and prepulse + pulse responses at each dose tested, ^*P < .05 compared with pulse alone. Data for % PPI were analyzed by analysis of variance followed by Dunnett’st test and were not significantly different.