Inhibition of purified ADA and ADA activity in intact HACs and human RBCs by EHNA and its analogs
| Compound | Soluble ADA Type IX calf spleen | Whole cells IC50 | |
|---|---|---|---|
| Human HACs | Human RBCs | ||
| KinM | μM | ||
| EHNA | 9.3 | 1.45 ± 0.1 | 1.20 + 0.7 |
| CPC-402 | 8.0 | 12.72 ± 3.2 | N.D. |
| CPC-405 | 2.7 | 2.61 ± 0.5 | 0.22 + 0.1 |
| CPC-406 | 0.95 | 0.75 ± 0.3 | N.D. |
| CPC-407 | 7.4 | 4.08 ± 0.9 | N.D. |
| CPC-410 | N.D. | 270.65 ± 65.1 | N.D. |
For experimental details, see the text.
N.D. = not determined.