Receptor Assay Radioligand Tissue Source | Rat SERT [3H]Citalopram Rat Cortex | Human SERT [3H]Citalopram Transfected Cells | Human SERT [3H]5-HT Transfected Cells |
---|---|---|---|
Nefazodone | 220 ± 4 | 459 ± 28 | 549 ± 26 |
Hydroxynefazodone | 612 ± 11 | 1,015 ± 27 | 1203 ± 23 |
Triazoledione | 26,471 ± 3,019 | 34,527 ± 6,773 | 70122 ± 4514 |
mCPP | 218 ± 7 | 202 ± 9 | 432 ± 24 |
Trazodone | 237 ± 16 | 252 ± 10 | 690 ± 47 |
Amitriptyline | 16 ± 0.8 | 2.8 ± 0.1 | 36 ± 1 |
Desipramine | 129 ± 7 | 22 ± 1 | 163 ± 5 |
Paroxetine | 0.05 ± 0.0003 | 0.065 ± 0.006 | 0.83 ± 0.06 |
Sertraline | 0.29 ± 0.01 | 0.15 ± 0.01 | 3.3 ± 0.4 |
Citalopram | 0.75 ± 0.002 | 1.5 ± 0.03 | 8.9 ± 0.7 |
Fluoxetine | 2.0 ± 0.1 | 0.90 ± 0.06 | 20 ± 2 |
Fluvoxamine | 1.5 ± 0.01 | 1.6 ± 0.1 | 14 ± 1 |
Venlafaxine | 19 ± 1.7 | 7.5 ± 0.4 | 102 ± 9 |
O-Desmethylvenlafaxine | 20 ± 0.1 | 7.7 ± 0.3 | 115 ± 6 |
Chloroimipramine | 0.47 | 0.05 ± 0.001 | ND |
Nortriptyline | 60 ± 3.3 | 15 ± 0.1 | 279 ± 20 |
Imipramine | 8.7 ± 0.04 | 1.3 ± 0.04 | 20 ± 2 |
Norfluoxetine | 1.9 ± 0.04 | 2.3 ± 0.10 | 54 ± 4 |
Desmethylsertraline | 4.6 ± 0.05 | 3.7 ± 0.26 | 187 ± 15 |
Receptor assay Radioligand Tissue source | rat NET [3H]Nisoxetine Rat Cortex | Human NET [3H]Nisoxetine Transfected Cells | Human NET [3H]NE Transfected Cells |
---|---|---|---|
Nefazodone | 555 ± 8 | 618 ± 12 | 713 ± 27 |
Hydroxynefazodone | 728 ± 32 | 664 ± 24 | 1,053 ± 49 |
Triazoledione | >100,000 | >100,000 | >100,000 |
mCPP | 699 ± 5 | 1,940 ± 152 | 4,360 ± 263 |
Trazodone | 20,887 ± 703 | 37,419 ± 1,433 | 30,751 ± 2,110 |
Amitriptyline | 8.6 ± 0.04 | 19 ± 1 | 102 ± 9 |
Desipramine | 0.31 ± 0.01 | 0.63 ± 0.03 | 3.5 ± 0.6 |
Paroxetine | 59 ± 0.7 | 85 ± 5 | 328 ± 25 |
Sertraline | 1,597 ± 44 | 817 ± 80 | 1,716 ± 151 |
Citalopram | 3,042 ± 58 | 7,865 ± 304 | 30,285 ± 1,600 |
Fluoxetine | 473 ± 11 | 777 ± 37 | 2,186 ± 142 |
Fluvoxamine | 940 ± 27 | 2,950 ± 103 | 4,743 ± 639 |
Venlafaxine | 1,067 ± 29 | 2,269 ± 84 | 1,644 ± 84 |
O-Desmethylvenlafaxine | 938 ± 86 | 2,753 ± 114 | 3,152 ± 103 |
Mazindol | 0.47 | 0.46 ± 0.004 | 1.93 |
Nortriptyline | 0.99 ± 0.03 | 1.8 ± 0.07 | 21 ± 0.77 |
Imipramine | 11 ± 0.74 | 20 ± 0.54 | 142 ± 8 |
Norfluoxetine | 4,997 ± 206 | 3,947 ± 222 | 3,050 ± 146 |
Desmethylsertraline | 3,411 ± 127 | 811 ± 17 | 2,365 ± 12 |
Receptor Assay Radioligand Tissue Source | 5-HT2A [3H]Ketanserin Rat Cortex | 5-HT1A [3H]8-OH-DPAT Rat Hippocampus | H1 [3H]Pyrilamine Guinea Pig Brain | Alpha-1 [3H]Prazosin Human Cortex | Alpha-2 [3H]Rauwolscine Human Cortex | Muscarinic [3H]NMS3-b Rat Cortex |
---|---|---|---|---|---|---|
Nefazodone | 7.1 ± 0.4 | 52 ± 1 | 30 ± 1 | 5.5 ± 0.3 | 84 ± 4 | 4,569 ± 42 |
Hydroxynefazodone | 7.2 ± 0.4 | 56 ± 1 | 28 ± 0.2 | 8.0 ± 0.4 | 63 ± 2 | 11,357 ± 313 |
Triazoledione | 159 ± 16 | 1,371 ± 42 | 11 ± 0.9 | 173 ± 4 | 1,915 ± 90 | >100,000 |
mCPP | 110 ± 3 | 16 ± 0.2 | 449 ± 10 | 97 ± 3 | 112 ± 6 | 4,702 ± 59 |
Trazodone | 20 ± 1 | 42 ± 1 | 29 ± 1 | 12 ± 0.2 | 106 ± 2 | 12,188 ± 185 |
Amitriptyline | 5.3 ± 0.2 | 129 ± 2 | 0.17 ± 0.01 | 4.4 ± 0.2 | 114 ± 2 | 2.6 ± 0.1 |
Desipramine | 115 ± 13 | 2,272 ± 10 | 31 ± 1 | 23 ± 1 | 1,379 ± 39 | 37 ± 1 |
Paroxetine | 6,320 ± 608 | 21,168 ± 2401 | 13,746 ± 404 | 995 ± 35 | 3,915 ± 114 | 42 ± 2 |
Sertraline | 2,207 ± 60 | 3,663 ± 82 | 5,042 ± 165 | 36 ± 2 | 477 ± 17 | 232 ± 11 |
Fluoxetine | 141 ± 9 | 8,313 ± 62 | 933 ± 23 | 1,353 ± 17 | 3,090 ± 121 | 512 ± 12 |
Venlafaxine | >100,000 | >100,000 | 12,909 ± 1,075 | 39,921 ± 810 | >100,000 | 29,966 ± 1,464 |
Cinanserin | 3.5 | |||||
Serotonin | 0.12 | |||||
Chlorpheniramine | 0.44 | |||||
Phentolamine | 3.4 | |||||
Yohimbine | 0.71 | |||||
Atropine | 0.080 |