The mean IC50 values of antimalarials for quinine 3-hydroxylation with microsomes obtained from rat, dog and human livers (n = 3)
| Antimalarial | IC50 (μM) | ||
|---|---|---|---|
| Rat | Dog | Human | |
| Primaquine | 37.5 | 40.5 | 19.4 |
| Doxycycline | 62.4 | 64.0 | 16.43-a |
| Tetracycline | 117.7 | 119.0 | 32.63-a |
| Chloroquine | 47.2 | >200 | >200 |
| Proguanil | >200 | >200 | >200 |
↵3-a P < .01 compared with the rat or dog group.