SR141716A | PMSF | % MPE | % inhibition | Δ°C | % immobility |
---|---|---|---|---|---|
mg/kg | |||||
3 | 0 | 7 ± 5 | 4 ± 11 | −1.6 ± 0.3 | 2 ± 1 |
0 | 100 | 49 ± 14 | 85 ± 6 | −3.7 ± 0.4 | 22 ± 6 |
3 | 100 | 39 ± 15 | 74 ± 8 | −4.1 ± 0.3 | 18 ± 5 |
Mice were injected i.v. with SR 141716A 10 min before the i.p. administration of either PMSF or its vehicle (sesame oil) before testing as described under “Materials and Methods.” Values (mean ± S.E.M., n = 6 per group) for tail-flick antinociception (% MPE), inhibition of locomotor activity (% inhibition), decrease in core temperature (Δ°C) and ring-immobility catalepsy (% immobility) after i.p. administration of PMSF. PMSF alone (in the absence of antagonist) was statistically different (P < .05) from both vehicle control (1:1:18 vehicle + sesame oil) (data not shown) and the drug control (SR141716A + sesame oil) but not from the SR 141716A/PMSF combination.