Effects of SB 217242 on irET plasma concentrations in normal and hypoxic guinea pigs1-a
| Treatment | ir-ET (pg/ml) | n |
|---|---|---|
| Normoxic, vehicle | 12.8 ± 1.8 | 4 |
| Hypoxic, vehicle | 35.4 ± 7.7* | 6 |
| Hypoxic, SB 217242, 0.36 mg/day | 9.5 ± 4.6** | 6 |
| Hypoxic, SB 217242, 3.6 mg/day | 5.1 ± 1.0** | 5 |
| Hypoxic, SB 217242, 10.8 mg/day | 40.6 ± 7.1* | 8 |
| Normoxic, SB 217242, 10.8 mg/day | 9.5 ± 3.5 | 8 |
↵1-a SB 217242 or vehicle was delivered intraperitoneally by mini osmotic pump for 10 days. Results are expressed as mean ± S.E.M.
* P < .05 ANOVA, Fisher’s PLSD, compared to normoxic.
** P < .05 ANOVA, Fisher’s PLSD, compared to hypoxic vehicle.