Table 1

Recovered percentage of [³H]PAH and [¹⁴C]inulin in the ipsilateral, contralateral cerebrum, cerebellum or CSF after intracerebral microinjection

Time after administration (min)	n	Remaining Percentage Relative to the Injected Amount^1-a
Time after administration (min)	n	Ipsilateral Cerebrum	Contralateral Cerebrum	Cerebellum	CSF
[³H]PAH
2	3	82.9 ± 6.1	N.D.	N.D.	N.D.
5	3	85.1 ± 9.1	N.D.	N.D.	N.D.
20	3	60.5 ± 7.6	N.D.	N.D.	N.D.
[¹⁴C]Inulin
2	3	119.0 ± 7.8	N.D.	N.D.	N.D.
5	3	127.0 ± 11.1	N.D.	N.D.	N.D.
20	3	109.4 ± 16.7	N.D.	N.D.	N.D.

[³H]PAH (0.2 μCi) and [¹⁴C]inulin (1.5 nCi) dissolved in 0.5 μl ECF buffer were injected intracerebrally for 1 sec into normal male rats. Rats were decapitated 2, 5 and 20 min after administration. In this experiment, the detection limits were 0.050% ([³H]PAH) and 2.9% ([¹⁴C]inulin) of the administered dose.

↵1-a Each value represents the mean ± S.E. N.D., not detected.