Species | Dose | Cmax | Systemic plasma clearance | Vss | Apparent t1/2elimination |
---|---|---|---|---|---|
mg/kg | μg/ml | ml/min/kg | l/kg | hr | |
Rat | 10 (1) | 39.8 ± 2.5 (1) | 11.7 ± 2.0 | 0.32 ± 0.10 | 0.8 ± 0.2 |
60 (2) | 18.9 ± 5.1 (2) | ||||
Dog | 5–6 | 61.7–76.1 (1) | 2.89 ± 0.82 | 0.11 ± 0.04 | 0.9 ± 0.2 |
Rabbit | 10 | 26.8 ± 5.5 | 26.8 ± 7.3 | 1.38 ± 0.09 | 2.6 ± 0.6 |
Cynomolgus monkey2-a | 10 | 37.8–52.6 | 15.1–18.8 | 0.16–0.24 | 0.5–0.6 |
Rhesus monkey | 10 | 35.9 ± 12.7 | 19.0 ± 4.5 | 0.36 ± 0.26 | 0.8 ± 0.2 |
Cmax, maximal achieved plasma concentration at 5 min after dosing; Vss, volume of distribution at steady state. Data were obtained after single dose intravenous administration (1) or 6-h intravenous infusion (2). Value are mean ± S.D. from 3 to 7 animals.
↵2-a Individual values, n = 2.