Control of lymphoproliferative disease in MRL-lpr/lprmice1-a
| Weight (g) | ||
|---|---|---|
| Lymph nodes | Thymus | |
| Untreated | 2.97 ± 0.29 | 0.38 ± 0.09 |
| Uridine | 2.58 ± 0.58 | 0.24 ± 0.08 |
| BQR | 0.35 ± 0.081-b | 0.12 ± 0.011-d |
| BQR + uridine | 1.26 ± 0.21-c,1-d | 0.15 ± 0.051-c |
↵1-a MRL-lpr/lpr mice (four to six mice in each group) were treated with uridine only (500 mg/kg, twice daily), BQR only (10 mg/kg/day), BQR (10 mg/kg/day) plus uridine (500 mg/kg, twice daily) for 7 wk. Controls were age-matched untreated MRL-lpr/lpr mice. Mice were killed, total lymph nodes and thymus were collected and weighed.
↵1-b P < .01 compared to untreated control.
↵1-c P < .05 compared to untreated control.
↵1-d P < .05 compared to that of BQR-treated animals.