Effect of A-61603 pretreatment on the inhibition of developed tension produced by 10 nM PBZ
| Tissue | Developed tension | |||
|---|---|---|---|---|
| Control | A-61603 alone | PBZ alone | A-61603 + PBZ | |
| g | ||||
| Aorta | 1.21 ± 0.26 | 0.86 ± 0.12 | 0.27 ± 0.08 | 0.4 ± 0.12 |
| Caudal | 1.37 ± 0.28 | 1.47 ± 0.14 | 0.69 ± 0.12 | 1.29 ± 0.174-a |
| Femoral | 1.18 ± 0.11 | 1.03 ± 0.01 | 0.12 ± 0.03 | 0.35 ± 0.064-a |
| Iliac | 1.11 ± 0.02 | 1.25 ± 0.35 | 0.31 ± 0.08 | 0.35 ± 0.035 |
| Mesenteric resistance | 1.85 ± 0.17 | 1.73 ± 1.8 | 0.02 ± 0.01 | 0.04 ± 0.01 |
| Renal | 0.95 ± 0.13 | 1.04 ± 0.1 | 0.52 ± 0.6 | 0.7 ± 0.094-a |
| Superior Mesenteric | 0.88 ± 0.06 | 1.05 ± 0.09 | 0.13 ± 0.09 | 0.2 ± 0.11 |
↵4-a Statistically greater response than PBZ alone.