Table 2

Effect of BMY 7378 pretreatment on the inhibition of developed tension produced by 10 nM PBZ

TissueDeveloped tension
ControlBMY 7378 alonePBZ30 nM BMY 7378 + PBZ100 nM BMY 7378 + PBZ
g
Aorta1.25  ± 0.091.14  ± 0.190.65  ± 0.161.12  ± 0.182-a N.D.
Caudal1.32  ± 0.171.27  ± 0.241.24  ± 0.161.33  ± 0.321.39  ± 0.22
Femoral0.83  ± 0.080.87  ± 0.060.05  ± 0.010.25  ± 0.132-a 0.5  ± 0.12-a
Iliac1.29  ± 0.170.82  ± 0.190.26  ± 0.120.47  ± 0.122-a 0.63  ± 0.072-a
Mesenteric resistance1.15  ± 0.151.2  ± 0.040.04  ± 0.010.04  ± 0.010.03  ± 0.02
Renal0.73  ± 0.140.68  ± 0.110.29  ± 0.10.36  ± 0.050.38  ± 0.02
Superior Mesenteric1.03  ± 0.210.94  ± 0.240.18  ± 0.020.5  ± 0.052-a 0.62  ± 0.112-a
  • 2-a Statistically greater than the response to PBZ alone.

  • N.D., not determined.