Cumulative REM sleep loss and recovery (minutes)4-a
| n | Total REM Sleep Deficit | Total REM Sleep Recovered | |||||
|---|---|---|---|---|---|---|---|
| Mean | S.E. | Duration | Mean | S.E. | Duration | ||
| MOD 300 | 10 | −30.2 | 4.4 | First 8 h post-treatment | 17.3 | 4.2 | h 9–24 |
| Vehicle | 20 | −0.5 | 1.7 | 3.1 | 2.3 | ||
| METH 1.0 | 9 | −28.1 | 3.4 | First 5 h | 21.8 | 6.4 | h 6–24 |
| Vehicle | 20 | −5.2 | 1.9 | 7.3 | 2.6 | ||
| MOD 100 | 12 | −17.4 | 1.1 | First 3 h | 15.1 | 2.2 | h 4–24 |
| Vehicle | 20 | −5.7 | 1.2 | 5.8 | 2.8 | ||
| METH 0.5 | 10 | −19.8 | 3.3 | First 4 h | 17.6 | 4.3 | h 5–24 |
| Vehicle | 20 | −5.7 | 1.5 | 8.5 | 2.2 | ||
| MOD 30 | 9 | −10.7 | 0.8 | First 2 h | 6.0 | 4.3 | h 3–24 |
| Vehicle | 20 | −5.6 | 1.0 | 7.6 | 2.9 | ||
| ANOVA | REM Sleep Deficit | Total REM Recovered | ||
|---|---|---|---|---|
| F | P | F | P | |
| Main effect (dF = 9,149) | 23.73 | 0.0001 | 3.23 | 0.002 |
| Planned Contrasts | ||||
| MOD 300-Vehicle | 104.02 | 0.0001 | 8.86 | 0.0034 |
| METH 1.0-Vehicle | 57.88 | 0.0001 | 8.64 | 0.0039 |
| METH 1.0-MOD 300 | 0.34 | N.S. | 0.64 | N.S. |
| MOD 100-Vehicle | 18.05 | 0.0001 | 4.28 | 0.0403 |
| METH 0.5-Vehicle | 23.68 | 0.0001 | 3.69 | N.S. |
| METH 0.5-MOD 100 | 0.57 | N.S. | 0.23 | N.S. |
| MOD 30-Vehicle | 2.93 | N.S. | 0.10 | N.S. |
↵4-a MOD, modafinil; METH, methamphetamine. Values stated for MOD and METH are in milligrams per kilogram i.p.