n | NREM Sleep Recovery | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
NREM Sleep Deficit | “Immediate” Recovery | Total Recovery as of 24-h Post-treatment | ||||||||
Mean | S.E. | Duration | Mean | S.E. | Duration | Mean | S.E. | Duration | ||
MOD 300 | 10 | −83.9 | 7.1 | First 4 h post-treatment | 15.2 | 5.0 | h 5–9 post-treatment | 54.3 | 11.1 | h 5–24 post-treatment |
Vehicle | 20 | −5.6 | 3.1 | 8.4 | 3.1 | 15.2 | 5.7 | |||
METH 1.0 | 9 | −91.9 | 8.5 | 38.5 | 5.1 | 57.7 | 8.7 | |||
Vehicle | 20 | −6.8 | 3.2 | 6.4 | 3.1 | 14.2 | 6.2 | |||
MOD 100 | 12 | −50.3 | 5.1 | First 3 h post-treatment | 15.1 | 3.6 | h 4–6 post-treatment | 47.7 | 5.1 | h 4–24 post-treatment |
Vehicle | 20 | −8.3 | 2.7 | 6.7 | 2.1 | 14.1 | 5.8 | |||
METH 0.5 | 10 | −64.3 | 5.3 | 22.6 | 2.9 | 56.9 | 6.8 | |||
Vehicle | 20 | −9.7 | 2.7 | 7.4 | 1.8 | 20.0 | 5.0 | |||
MOD 30 | 9 | −23.1 | 4.7 | First 2 h post-treatment | 15.9 | 11.2 | h 3–24 post-treatment | |||
Vehicle | 20 | −11.1 | 2.3 | 17.1 | 5.5 |
ANOVA | NREM Sleep Deficit | Immediate Recovery | Total NREM Recovered | |||
---|---|---|---|---|---|---|
F | P | F | P | F | P | |
Main effect (dF = 9,149) | 61.04 | 0.0001 | 4.19 | 0.0001 | 7.21 | 0.0001 |
Planned contrasts | ||||||
MOD 300-Vehicle | 178.39 | 0.0001 | 1.16 | N.S. | 15.25 | 0.0001 |
METH 1.0-MOD 300 | 1.31 | N.S. | 9.70 | 0.0022 | 0.08 | N.S. |
METH 1.0-Vehicle | 195.79 | 0.0001 | 24.11 | 0.0001 | 17.55 | 0.0001 |
MOD 100-Vehicle | 57.47 | 0.0001 | 2.01 | N.S. | 12.63 | 0.0005 |
METH 0.5-Vehicle | 86.33 | 0.0001 | 5.80 | 0.0173 | 13.60 | 0.0003 |
METH 0.5-MOD 100 | 4.66 | 0.0326 | 1.15 | N.S. | 0.69 | N.S. |
MOD 30-Vehicle | 3.92 | 0.0498 | 0.04 | N.S. | 0.01 | N.S. |
↵3-a MOD, modafinil; METH, methamphetamine. Values stated for MOD and METH are in milligrams per kilogram i.p.