Treatment effects during the first 2 h2-a
| Wake | NREM | REM | LMA | LMA Intensity | Wake Bouts | Body Temp | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean | S.E. | Mean | S.E. | Mean | S.E. | n | Mean | S.E. | n | Mean | S.E. | n | Mean | S.E. | n | Mean | S.E. | |
| MOD 300 | 10 | 56.9 | 1.2 | 2.7 | 1.1 | 0.5 | 0.2 | 11 | 131.3 | 16.6 | 8 | 2.51 | 0.37 | 10 | 73.0 | 11.0 | 11 | −0.23 | 0.07 |
| Vehicle | 20 | 30.5 | 1.0 | 26.1 | 0.8 | 3.4 | 0.4 | 20 | 89.2 | 4.7 | 20 | 2.49 | 0.15 | 20 | 6.5 | 1.1 | 20 | 0.01 | 0.04 |
| MOD 100 | 12 | 50.0 | 2.8 | 8.9 | 2.4 | 1.1 | 0.5 | 11 | 116.5 | 11.1 | 10 | 2.45 | 0.26 | 12 | 28.9 | 4.5 | 11 | −0.02 | 0.06 |
| Vehicle | 20 | 30.4 | 1.0 | 26.0 | 0.8 | 3.6 | 0.4 | 20 | 93.8 | 4.6 | 20 | 2.51 | 0.14 | 20 | 5.9 | 0.9 | 20 | −0.01 | 0.04 |
| MOD 30 | 9 | 36.5 | 2.2 | 21.5 | 2.0 | 2.0 | 0.4 | 11 | 86.3 | 10.1 | 9 | 2.42 | 0.26 | 9 | 10.6 | 2.5 | 11 | −0.07 | 0.07 |
| Vehicle | 20 | 31.0 | 0.9 | 25.6 | 0.8 | 3.4 | 0.4 | 20 | 85.5 | 5.2 | 20 | 2.51 | 0.16 | 20 | 5.8 | 0.9 | 20 | −0.05 | 0.04 |
| METH 1.0 | 9 | 55.5 | 1.2 | 3.8 | 1.0 | 0.7 | 0.2 | 13 | 250.4 | 8.7 | 8 | 4.71 | 0.22 | 7 | 27.2 | 6.4 | 12 | 0.55 | 0.07 |
| Vehicle | 20 | 31.0 | 1.2 | 25.9 | 0.9 | 3.1 | 0.3 | 20 | 87.2 | 6.4 | 20 | 2.50 | 0.16 | 20 | 5.7 | 0.9 | 20 | −0.00 | 0.04 |
| METH 0.5 | 10 | 53.9 | 1.1 | 4.8 | 0.7 | 1.3 | 0.5 | 12 | 200.8 | 10.1 | 9 | 3.74 | 0.23 | 9 | 22.0 | 3.0 | 10 | 0.29 | 0.08 |
| Vehicle | 20 | 30.8 | 1.0 | 25.9 | 0.8 | 3.3 | 0.3 | 20 | 80.5 | 5.9 | 20 | 2.19 | 0.16 | 20 | 5.9 | 0.9 | 20 | −0.03 | 0.03 |
| ANOVA Main effect across treatment groups | Significant Contrasts (P < .05) | ||||||
|---|---|---|---|---|---|---|---|
| vs. Vehicle | Between “Comparable” Doses | ||||||
| MOD | METH | METH 0.5 vs.MODAF 100 | METH 1.0 vs. MODAF 300 | ||||
| 30 | 100 | 300 | 0.5 | 1.0 | |||
| Wake:F[9,149] = 64.36, P < .0001 | .0089 | .0001 | .0001 | .0001 | .0001 | – | – |
| LMA: F[9,157] = 50.60, P < .0001 | – | .0482 | .0003 | .0001 | .0001 | .0001 | .0001 |
| LMA intensity: F[9,143] = 11.15, P < .0001 | – | – | – | .0001 | .0001 | .0001 | .0001 |
| NREM sleep: F[9,149] = 74.79, P < .0001 | .0176 | .0001 | .0001 | .0001 | .0001 | .0280 | – |
| REM sleep: F[9,149] = 9.20, P < .0001 | .0237 | .0001 | .0001 | .0009 | .0001 | – | – |
| Wake bouts: F[9,149] = 38.43, P < .0001 | – | .0001 | .0001 | .0006 | .0001 | – | .0001 |
| Tb: F[9,154] = 16.41, P < .0001 | – | – | .0008 | .0001 | .0001 | .0002 | .0001 |
↵2-a MOD, modafinil; METH, methamphetamine; (Values with MOD and METH are stated in milligrams per kilogram i.p.) Tb, body temperature; –, P > .05.