Relative potency for suppressing morphine withdrawal
| Relative potency | Relative potency | |
|---|---|---|
| Morphine | 1.00 | |
| (standard) | ||
| Methadone | 1.1 | |
| (0.3–2.7) | ||
| LAAM | 0.5 | 1.00 |
| (0.09–2.0) | (standard) | |
| nor-LAAM | 9.33-a | |
| (2.9–20) | ||
| dinor-LAAM | 1.0 | |
| (0.5–3.3) |
Relative potency estimates, with 95% confidence limits shown in parentheses, were based on suppression scores obtained 40 hr after withdrawal from morphine and are presented only for valid, parallel line bioassay ANOVAs as defined and described in table 2.
↵3-a Confidence limits not including 1.00 represent a significant difference between the standard and test drugs. When morphine was used as the standard drug, there was only one valid bioassay and no difference between the two potencies.
Right column, LAAM was used as the standard drug, and valid bioassays were obtained for all comparisons except with morphine. Note that parallel-line bioassays and relative potency estimates were determined from dose-response curves for which the points are connected by a solid line in figure 7 (i.e., the ceiling effect was excluded).