Human liver microsomal CYP2C9 and CYP2A6-dependent catalytic activities
| Liver Sample | (S)-Warfarin-7-Hydroxylation (pmol/nmol/min) | Coumarin 7-Hydroxylation (nmol/nmol/min) |
|---|---|---|
| HL102 | 20.0 | 8.9 |
| HL110 | 11.3 | 5.1 |
| HL112 | 11.0 | 1.8 |
| HL113 | 16.0 | 5.3 |
| HL122 | 27.3 | 6.9 |
| HL123 | 15.0 | 1.2 |
| HL125 | 23.3 | 2.2 |
| HL131 | 16.7 | 17.3 |
The rate of formation of (S)-7-hydroxywarfarin and 7-hydroxycoumarin were measured by GC/MS and fluorescence spectroscopy, respectively, as described under “Materials and Methods.” Each value is the mean of duplicate determinations.