Effect of PYY on PGE2 -treated control and infected ileum
| n | Na+ | Cl− | Isc | G | |||||
|---|---|---|---|---|---|---|---|---|---|
| Jms | Jsm | Jnet | Jms | Jsm | Jnet | ||||
| μEq/hr/cm 2 | μEq/hr/cm 2 | mS/cm 2 | |||||||
| Control piglets | |||||||||
| Effect of PGE2 | |||||||||
| Indomethacin | 4 | 15.1 ± 0.8 | 12.8 ± 0.7 | 2.3 ± 0.9 | 9.6 ± 0.4 | 6.5 ± 0.5 | 3.1 ± 0.7 | −0.3 ± 0.1 | 31.2 ± 2.3 |
| PGE2 | 4 | 10.1 ± 0.73-a | 9.9 ± 0.43-a | 0.2 ± 0.63-a | 4.3 ± 0.73-a | 6.6 ± 0.3 | −2.3 ± 0.93-a | 2.1 ± 0.33-a | 22.9 ± 1.03-a |
| Effect of PGE2 + PYY | |||||||||
| Indomethacin | 4 | 14.7 ± 0.7 | 13.0 ± 1.1 | 2.5 ± 1.1 | 9.9 ± 0.7 | 6.2 ± 0.5 | 3.7 ± 0.4 | −0.2 ± 0.1 | 29.1 ± 1.7 |
| PGE2 + PYY | 4 | 11.1 ± 1.83-a | 9.4 ± 0.53-a | 1.7 ± 1.6 | 4.8 ± 0.83-a | 6.7 ± 0.4 | −2.0 ± 1.13-a | 2.4 ± 0.33-a | 22.5 ± 1.43-a |
| Infected piglets | |||||||||
| Effect of PGE2 | |||||||||
| Indomethacin | 4 | 14.4 ± 2.1 | 12.1 ± 1.0 | 2.3 ± 1.6 | 9.0 ± 0.8 | 5.7 ± 0.5 | 3.4 ± 0.9 | −0.1 ± 0.1 | 24.6 ± 1.8 |
| PGE2 | 4 | 9.3 ± 1.43-a | 9.4 ± 0.43-a | −0.2 ± 1.43-a | 5.2 ± 0.53-a | 6.6 ± 0.2 | −1.4 ± 0.63-a | 2.3 ± 0.33-a | 19.5 ± 1.03-a |
| Effect of PGE2 + PYY | |||||||||
| Indomethacin | 4 | 12.9 ± 1.6 | 9.5 ± 1.2 | 3.4 ± 0.5 | 8.2 ± 1.2 | 6.1 ± 1.0 | 2.1 ± 0.3 | 0.7 ± 0.5 | 22.8 ± 3.7 |
| PGE2 + PYY | 4 | 8.8 ± 1.33-a | 8.2 ± 0.9 | 0.7 ± 0.53-a | 5.3 ± 1.13-a | 6.7 ± 0.8 | −1.5 ± 0.53-a | 1.9 ± 0.63-a | 19.5 ± 3.43-a |
PGE2 (10−6 M) or PGE2 (10−6 M) plus PYY (10−7 M) were added 20 min before second flux period.
↵3-a P < .05, paired comparisons of indomethacin and PGE2 or indomethacin and PGE2 + PYY.
Values are mean ± S.E.M. of n piglets.