Relative potencies of Dyn A and related peptides and fragments in competing with the binding of [3H]MK-801 to rat brain membranes
| Peptide | Ki | Potency ratio |
|---|---|---|
| μM | % | |
| Opioid peptide | ||
| Dyn A-(1–13) | 0.21 ± 0.04 | 100 |
| Dyn A | 0.41 ± 0.013-b | 51 |
| Dyn A-(1–9) | 1.23 ± 0.323-b | 17 |
| Dyn B | 2.34 ± 0.403-b | 9 |
| α-Neo-End | 3.66 ± 0.423-b | 6 |
| Dyn A-(1–8) | 6.25 ± 0.273-b | 3 |
| Leu-Enk | N.A.3-a | |
| Nonopioid peptide | ||
| [Ala1]Dyn A-(1–13) | 0.88 ± 0.113-b | 24 |
| Dyn A-(2–13) | N.A.3-a | |
| Dyn A-(3–13) | N.A.3-a | |
| Dyn A-(2–8) | N.A.3-a | |
| Dyn A-(6–10) | N.A.3-a |