Drug | n | Dose (mg/kg) | Peak Drug Effect | Peak Cocaine Effect3-a | ||
---|---|---|---|---|---|---|
Arterial pressure (mm Hg) | Heart rate (beats/min) | Arterial pressure (mm Hg) | Heart rate (beats/min) | |||
Bromocriptine | 12 | 0.1 | 20.4 ± 3.73-b | 5 ± 9 | 17.7 ± 3.13-c | 26 ± 11 |
6 | 1.0 | 12.8 ± 2.83-b | −25 ± 17 | 7.3 ± 4.43-c | 11 ± 13 | |
Desipramine | 13 | 1.0 | 20.7 ± 2.13-b | −16 ± 63-b | 44.7 ± 4.1 | 12 ± 13 |
5 | 10 | 18.8 ± 2.63-b | 37 ± 26 | 26 ± 3.33-a | −53 ± 8 | |
GBR12909 | 10 | 0 | 10.2 ± 2.53-b | 27 ± 53-b | 49.4 ± 3.3 | 5 ± 13 |
9 | 0.5 | 6.8 ± 2.83-b | 31 ± 43-b | nt3-d | nt | |
15 | 1.0 | 7.3 ± 3.3 | 32 ± 53-b | 47.7 ± 2.9 | 29 ± 9 | |
10 | 5 | −4.2 ± 4.0 | 40 ± 73-b | nt 3-d | nt | |
2 | 10 | 22 ± 1.4 | 68 ± 13-b | nt 3-d | nt | |
Diazepam | 12 | 0.1 | 10.8 ± 1.73-b | 11 ± 7 | 42.7 ± 5.13-c | 25 ± 9 |
6 | 0.5 | 6.5 ± 1.03-b | 33 ± 93-b | 46.8 ± 3.7 | 16 ± 18 | |
6 | 1.0 | 17.5 ± 2.43-b | 56 ± 83-b | 46.8 ± 2.5 | 6 ± 19 |