Change in baseline values
| Study | Group | n | Dose | Arterial Pressure | Heart Rate (Beats/Min) | Cardiac Output (% Change) | Systemic Vascular Resistance (% Change) | Stroke Volume (% Change) |
|---|---|---|---|---|---|---|---|---|
| (mg/kg) | (mm Hg) | |||||||
| Bromocriptine | MR | 6 | 0.1 | −4.2 ± 2.9 | 5.7 ± 6.4 | 1.3 ± 2.0 | −4.3 ± 4.6 | −0.3 ± 1.4 |
| VR | 6 | 0.1 | −11.7 ± 5.32-a | 0.3 ± 15.4 | −1.5 ± 1.2 | −9.4 ± 4.12-a | −1.1 ± 3.6 | |
| Desipramine | MR | 7 | 1 | 6.0 ± 1.32-a | −12.7 ± 3.4 | −2.9 ± 2.3 | 9.3 ± 3.12-a | 0.5 ± 2.5 |
| VR | 6 | 1 | 12.2 ± 2.02-a | −31.7 ± 11.32-a | −6.6 ± 2.42-a | 18.7 ± 3.12-a | 1.4 ± 1.6 | |
| GBR 12909 | MR | 5 | 1 | 9.2 ± 3.82-a | −1.0 ± 12.4 | 8.3 ± 4.32-a | 0.1 ± 3.3 | 9.9 ± 8.4 |
| VR | 10 | 1 | 6.6 ± 1.62-a | 12.9 ± 8.1 | 2.1 ± 1.6 | 3.5 ± 1.2 | −1.5 ± 1.4 | |
| Diazepam | MR | 5 | 0.1–0.5 | −4.2 ± 2.5 | 6.8 ± 8.9 | 5.7 ± 5.9 | −7.4 ± 5.2 | 4.2 ± 6.1 |
| VR | 13 | 0.1–0.5 | −4.6 ± 1.62-a | 1.8 ± 4.6 | 0.1 ± 0.7 | −3.8 ± 1.7 | −0.2 ± 1.5 | |
| Buprenorphine | VR | 7 | 0.1 | 21.4 ± 3.82-a | 48.1 ± 13.32-a | 5.0 ± 1.92-a | 13.2 ± 4.0 | −6.2 ± 3.1 |
| MK-801 | VR | 9 | 0.05 | 20.1 ± 2.82-a | 49.4 ± 6.22-a | 5.8 ± 1.22-a | 10.2 ± 1.82-a | −6.3 ± 1.3 |
Data were measured 5 min (bromocriptine and GBR 12909) or 10 min (all other drug treatments) after drug administration (immediately before cocaine administration) and compared to pre-drug control values. Group names refer to mixed responders (MR) and vascular responders (VR).
↵2-a Denotes significant drug-induced change from baseline as determined by two-way ANOVA.