Drug | ED50 (mg/kg) | Ratio | |
---|---|---|---|
Tiapride-lever selection | Response rate reduction | ||
Tiapride | 2.2 (1.2–3.8) | 41 (ND1-a) | 0.054 |
Amisulpride | 4 (2.1–7.6) | 24 (17–35) | 0.17 |
Sulpiride | 18 (5.4–33) | 74 (48–203) | 0.24 |
Sultopride | 1.5 (0.6–3.2) | 4.5 (2.6–9.8) | 0.33 |
Clebopride | 0.13 (ND) | 0.16 (0.14–0.19) | 0.81 |
Raclopride | 0.16 (0.066–2.6) | 0.13 (0.12–0.15) | 1.2 |
Metoclopramide | 1.4 (0.69–5) | 1.1 (ND) | 1.3 |
Remoxipride | 4.8 (2.1–18) | 2.6 (2.3–3) | 1.8 |
Pimozide | 2.7 (ND) | 4.3 (ND) | 0.63 |
Thioridazine | 3.4 (1.15–14) | 4.1 (ND) | 0.83 |
Olanzapine | 0.97 (0.54–2.9) | 0.93 (0.84–1) | 1 |
Clozapine | >10 | 4.8 (ND) | |
Chlorpromazine | 1.9 (ND) | 1.9 (ND) | 1 |
Risperidone | 0.22 (0.14–0.28) | 0.16 (0.14–0.18) | 1.4 |
Haloperidol | 0.14 (0.11–0.17) | 0.09 (0.074–0.10) | 1.6 |
Data are ED50 (95% confidence interval) based on six to eight rats, except for tiapride (n = 18). The ratio is the ED50 for substitution divided by ED50 for decreasing response rates.
↵1-a ND, Not determined.