Table 3

Kinetic parameters for CLup by bone marrow and spleen in control and EPO-treated rats

Km (ng/ml)Vmax (ng/g tissue/hr)CLns (ml/g tissue/hr)
Control
 Bone marrow16.8  (913 pM)20.3  ± 2.90.123  ± 0.032
±3.0
 Spleen23.8  (1290 pM)7.98  ± 1.00.111  ± 0.006
±3.6
EPO-treated
 Bone marrow12.3  (669 pM)21.4  ± 1.30.173  ± 0.018
±1.0
 Spleen8.54  (464 pM)13.2  ± 0.80.144  ± 0.014
±0.72 mg/ml
  • Each value represents the calculated mean ± S.E.; the values were estimated by equation 8; 12 rats/group were used.