Table 2

Kinetic parameters for CLup of rh-EPO

Km (ng/ml)Vmax (ng/g tissue/hr)CLns (ml/g tissue/hr)Vmax/Km + CLns (ml/kg B.W./hr)
Bone marrow8.26  (449 pM)15.9  ± 0.30.163  ± 0.00241.82-a
±0.23
Spleen4.42  (240 pM)4.56  ± 0.130.143  ± 0.0023.642-b
±0.23
• Each value represents the calculated mean ± S.E.; 21 rats were used.

• 2-a The bone marrow weight per kilogram of body weight was assumed to be 20 g (Dedrick et al., 1973).

• 2-b The spleen weight per kilogram of body weight was measured as 3.0 g.