Table 1

Pharmacokinetic parameters of rh-EPO after i.v. administration of rh-EPO to rats at doses of 0.2, 0.5, 1 and 5 μg/kg

Dose (μg/kg)T1/2 (β) (hr)Vc (ml/kg)Vss (ml/kg)MRT (h)CLtotal (ml/kg/h)AUC0–2/Dose (kg · h/ml)AUC0–8/Dose (kg · h/ml)AUC0–∞/Dose (kg · h/ml)
0.21.3249.685.21.1048.30.01410.0208
(0.12)(4.2)(1.4)(0.09)(3.9)(0.0006)(0.0016)
0.52.491-a 46.084.82.051-a 27.01-a 0.01931-a 0.03711-a
(0.38)(4.3)(3.5)(0.09)(0.3)(0.0000)(0.0004)
13.421-a 50.082.22.351-a 23.71-a 0.02241-a 0.03730.04231-a
(0.15)(1.1)(2.2)(0.08)(0.6)(0.0005)(0.0006)(0.0011)
52.361-a 47.577.82.331-a 24.31-a 0.02051-a 0.03770.04131-a
(0.16)(4.5)(3.8)(0.03)(1.8)(0.0011)(0.0027)(0.0029)
  • Each value represents mean (S.E.) of three animals.

  • 1-a Significant difference from 0.2 μg/kg (P < .05).