Table 2

Effect of linopirdine, nicotine and tacrine on the [³H]NE release from hippocampal slices induced by 100 μM NMDA in the absence or presence of 100 μM kynurenate (KYNA)^2-a

	Controls	NMDA (100 μM)	NMDA (100 μM) + KYNA (100 μM)
No drug added	–	423 ± 65	113 ± 32^2-b
Linopirdine
1 μM	n.d.	450 ± 30	109 ± 16^2-b
10 μM	27 ± 8.7	406 ± 26	171 ± 17^2-b
100 μM	19 ± 6.3	519 ± 44	127 ± 50^2-b
Nicotine
1 μM	n.d.	460 ± 49	105 ± 27^2-b
10 μM	27 ± 14	393 ± 28	99 ± 17^2-b
100 μM	101 ± 29	n.d.	n.d.
Tacrine
1 μM	n.d.	491 ± 36	128 ± 25^2-b
10 μM	39 ± 27	395 ± 28	152 ± 18^2-b
100 μM	147 ± 29	n.d.	n.d.

↵2-a Data (expressed as percent increase over basal) are means ± S.E.M. of four to six experiments run in triplicate. n.d. = not determined.
↵2-b P < .01 vs. NMDA.