Table 5

Prediction of in vivo CLint from in vitro metabolic data using liver microsomes prepared from each species

AnimalDose/AUCoral (ml/min/kg Liver)CLint, in vivo (ml/min/g Liver)CLint, in vitro (ml/min/g Liver)
Rat (n = 3)333030.438.8  (6.4)
Dog (n = 3)205  (68)3.40  (0.64)2.64  (0.64)
Human5-a (n = 6 or 125-b)11.1  (3.2)0.73  (0.27)0.94  (0.52)

  • Numbers in parentheses represent the S.D. of the mean values.

  • ↵5-a The human data were taken from Iwatsubo et al., 1997b.

  • ↵5-b n = 6 for Dose/AUCoral and CLint, in vivo; n = 12 for CLint, in vitro.