First Series | Leukocyte Adhesion (cells/10,000 μm2) | Rolling Leukocyte Flux (cells/min) | Total Leukocyte Flux (cells/min) | Leukocyte Rolling Fraction (%) |
---|---|---|---|---|
Control | 10.2 ± 3.6 | 26.6 ± 6.9 | 61.8 ± 11.6 | 41.0 ± 4.2 |
8.0 ± 9.5 | 45.0 ± 11.0 | |||
LTB4 | 18.2 ± 1.51-a | — | — | — |
53.0 ± 18.0 | ||||
Ropivacaine | 7.2 ± 1.7 | 7.4 ± 1.71-a | 32.8 ± 6.51-a | 21.8 ± 3.21-a |
3.0 ± 3.5 | 2.0 ± 0.5 | |||
LTB4 + ropivacaine | 8.4 ± 1.5b | — | — | — |
16.0 ± 2.5 |
Data were obtained from experiments described in figure 2. Values are expressed as means ± S.E.M. during a 2-min control period immediately before LTB4 challenge and at the last 2 min of ropivacaine and/or LTB4 application either in venules (bold) or postcapillary venules (italics). For clarity, data of no relevance to the effect of ropivacaine on LTB4-induced adhesion are replaced by dash (—).
↵1-a P < .05 compared with control value. b P < .05 compared with LTB4-induced value.