Table 5

Accuracy of t1/2 prediction methods derived by combination of clearance and volume of distribution predictions

MethodAverage-fold error (t1/2(predicted)/t1/2(actual))
V1V2V3aV3b
C1a2.55  (11)2.29  (11)2.82  (10)2.23  (10)
C1b6.74  (11)7.41  (11)7.54  (10)4.94  (10)
C1c2.73  (11)2.37  (11)3.05  (10)2.50  (10)
C1d7.37  (11)7.31  (11)8.22  (10)5.22  (10)
C2a2.83  (15)2.38  (14)2.13  (15)2.52  (15)
C2b5.19  (15)4.95  (14)8.02  (15)4.43  (15)
C2c3.26  (15)2.66  (14)2.13  (15)2.94  (15)
C2d5.44  (15)4.92  (14)8.25  (15)4.50  (15)
C3a3.47  (36)3.72  (34)5.15  (37)3.42  (37)
C3b4.06  (41)4.28  (38)3.51  (48)4.46  (39)
C3c3.35  (36)3.44  (34)4.39  (37)3.74  (37)
C3d3.18  (41)3.27  (38)4.38  (48)3.40  (39)
  • Numbers in parentheses indicate the number of predictions made that could be compared with authentic human in vivo data.