Table 1

Summary of pharmacokinetic and physicochemical properties of 50 compounds examined1-a

Compound No.Molecular weightAcid, base or neutralLipophilicityCLVDsst1/2FPlasma fuUrinary excretion
clogP ml/min/kg liter/kg hr % %
1454Base6.99160.01
2241Base2.910.9
3222Base1.484.00.73.5200.12<2
4311Base3.903.80.03
5412Base4.42122.32.8590.001<1
6296Base3.46156.64.71.00.19<1
7404Acid0.911.90.5160
8380Base4.107.40.07
9321Neutral5.101.2
10387Base5.9730<1
11339Acid4.801.30.09
12262Neutral0.62400.55
13291Acid2.675.50.02
14369Acid1.562.30.01
15620Neutral4.311.50.11
16740Neutral1.8345
17329Base0.19211.51.14.60.60<1
18327Base1.81165.54.30.60
19375Base4.37410.08
20414Base5.501.00.07
21236Neutral0.6443
22419Acid2.35270.006
23749Base1.83680.936
24342Base5.35260.02<1
25320Acid4.690.10.126890.001<2
26331Acid2.70450.00710
27338Acid4.84450.001<1
28452Base−0.5611700.2810
29373Acid5.59250.005<1
30428Acid5.534000.005<1
31465Acid4.61300.01<1
32318Neutral2.062.30.08<1
33299Base6.091.00.004<1
34451Base3.821.21.011690.01<1
35283Acid2.047.60.40.6700.1647
36408Base2.787.021.035640.03<1
37306Neutral−0.110.30.726800.8972
38283Acid4.020.9
39395Base4.008.015.1270.02<1
40253Base1.693.21.55.4930.4320
41376Base1.535.99.02.40.0259
42441Base1.584.32.87.6830.3665
43399Acid0.182.33.41.60.0161
44474Base2.289.81.54.0410.041
45439Base2.033.20.12<1
46418Base3.085.92.14.1460.128
47497Acid7.21160.001<1
48582Base5.222.50.01
49415Base5.44330.002
50426Base3.663.00.08<1
  • 1-a A blank entry indicates no data available.