Table 1

Effect of CGP 53716 on growth factor-induced DNA synthesis in cultured RASMC and balb/3T31-a

Growth FactorRASMC IC50 (μM)Balb/3T3 IC50 (μM)
PDGF-BB0.23  ± 0.010.17  ± 0.02
bFGF0.43  ± 0.071.10  ± 0.311-b
EGF0.79  ± 0.421-b 0.70  ± 0.11
  • 1-a Values are mean ± S.E.M. of three to eight experiments.

  • 1-b P < .05 vs. PDGF-BB within a cell type.