Table 1

Effect of rNAP5 on the hematologic parameters in conscious dogs

Dose (mg/kg)Time (hr)aPTT1-a(sec)PT (sec)ACT1-b (sec)Hb1-c(%)HCT1-d (%)Platelets (× 103/μL)
0.03024  ± 014  ± 088  ± 1191  ± 457  ± 5822  ± 242
(n = 4)132  ± 514  ± 0116  ± 10* 91  ± 360  ± 4841  ± 249
274  ± 8* 14  ± 0174  ± 2591  ± 056  ± 3736  ± 211
474  ± 11* 14  ± 0197  ± 9* 91  ± 353  ± 3674  ± 201
664  ± 8* 14  ± 0171  ± 4* 90  ± 455  ± 3717  ± 197
849  ± 914  ± 0138  ± 1290  ± 352  ± 3640  ± 178
2424  ± 014  ± 099  ± 1191  ± 352  ± 1624  ± 60
0.1024  ± 014  ± 093  ± 1191  ± 046  ± 6664  ± 44
(n = 4)1172  ± 5214  ± 0489  ± 18090  ± 440  ± 6606  ± 69
2214  ± 40* 14  ± 0821  ± 215* 91  ± 349  ± 8651  ± 82
4254  ± 0* 14  ± 01126  ± 217* 90  ± 448  ± 9633  ± 20
6245  ± 9* 14  ± 0886  ± 147* 90  ± 042  ± 6528  ± 46
8232  ± 22* 14  ± 0594  ± 69* 90  ± 345  ± 5574  ± 47
2439  ± 614  ± 0147  ± 2290  ± 549  ± 2605  ± 30
0.3024  ± 014  ± 090  ± 1291  ± 049  ± 6564  ± 75
(n = 4)1254  ± 0* 25  ± 61245  ± 255* 91  ± 057  ± 4572  ± 70
2254  ± 0* 35  ± 71500  ± 0* 91  ± 059  ± 4606  ± 56
4254  ± 0* 30  ± 3* 1500  ± 0* 91  ± 352  ± 6593  ± 60
6254  ± 0* 26  ± 3* 1500  ± 0* 90  ± 344  ± 6532  ± 55
8254  ± 0* 20  ± 21500  ± 0* 90  ± 349  ± 5545  ± 73
2443  ± 814  ± 0126  ± 6* 91  ± 346  ± 3548  ± 22
  • 1-a 254 sec is the maximum readable value.

  • 1-b 1500 sec is the maximum readable value.

  • 1-c Hb: hemoglobin.

  • 1-d HCT: hematocrit.

  • * P < .05 as compared with base line.