Dose (mg/kg) | Time (hr) | aPTT1-a(sec) | PT (sec) | ACT1-b (sec) | Hb1-c(%) | HCT1-d (%) | Platelets (× 103/μL) |
---|---|---|---|---|---|---|---|
0.03 | 0 | 24 ± 0 | 14 ± 0 | 88 ± 11 | 91 ± 4 | 57 ± 5 | 822 ± 242 |
(n = 4) | 1 | 32 ± 5 | 14 ± 0 | 116 ± 10* | 91 ± 3 | 60 ± 4 | 841 ± 249 |
2 | 74 ± 8* | 14 ± 0 | 174 ± 25 | 91 ± 0 | 56 ± 3 | 736 ± 211 | |
4 | 74 ± 11* | 14 ± 0 | 197 ± 9* | 91 ± 3 | 53 ± 3 | 674 ± 201 | |
6 | 64 ± 8* | 14 ± 0 | 171 ± 4* | 90 ± 4 | 55 ± 3 | 717 ± 197 | |
8 | 49 ± 9 | 14 ± 0 | 138 ± 12 | 90 ± 3 | 52 ± 3 | 640 ± 178 | |
24 | 24 ± 0 | 14 ± 0 | 99 ± 11 | 91 ± 3 | 52 ± 1 | 624 ± 60 | |
0.1 | 0 | 24 ± 0 | 14 ± 0 | 93 ± 11 | 91 ± 0 | 46 ± 6 | 664 ± 44 |
(n = 4) | 1 | 172 ± 52 | 14 ± 0 | 489 ± 180 | 90 ± 4 | 40 ± 6 | 606 ± 69 |
2 | 214 ± 40* | 14 ± 0 | 821 ± 215* | 91 ± 3 | 49 ± 8 | 651 ± 82 | |
4 | 254 ± 0* | 14 ± 0 | 1126 ± 217* | 90 ± 4 | 48 ± 9 | 633 ± 20 | |
6 | 245 ± 9* | 14 ± 0 | 886 ± 147* | 90 ± 0 | 42 ± 6 | 528 ± 46 | |
8 | 232 ± 22* | 14 ± 0 | 594 ± 69* | 90 ± 3 | 45 ± 5 | 574 ± 47 | |
24 | 39 ± 6 | 14 ± 0 | 147 ± 22 | 90 ± 5 | 49 ± 2 | 605 ± 30 | |
0.3 | 0 | 24 ± 0 | 14 ± 0 | 90 ± 12 | 91 ± 0 | 49 ± 6 | 564 ± 75 |
(n = 4) | 1 | 254 ± 0* | 25 ± 6 | 1245 ± 255* | 91 ± 0 | 57 ± 4 | 572 ± 70 |
2 | 254 ± 0* | 35 ± 7 | 1500 ± 0* | 91 ± 0 | 59 ± 4 | 606 ± 56 | |
4 | 254 ± 0* | 30 ± 3* | 1500 ± 0* | 91 ± 3 | 52 ± 6 | 593 ± 60 | |
6 | 254 ± 0* | 26 ± 3* | 1500 ± 0* | 90 ± 3 | 44 ± 6 | 532 ± 55 | |
8 | 254 ± 0* | 20 ± 2 | 1500 ± 0* | 90 ± 3 | 49 ± 5 | 545 ± 73 | |
24 | 43 ± 8 | 14 ± 0 | 126 ± 6* | 91 ± 3 | 46 ± 3 | 548 ± 22 |