Influence of dosing time of IFN-α (10.0 MIU/kg i.v.) injection on pharmacokinetic parameters
| Pharmacokinetic Parameter | Time of Injection (clock hours) | Statistical Significance | |
|---|---|---|---|
| 17:00 | 05:00 | ||
| CL (L/hr/kg) | 0.155 ± 0.008 | 0.125 ± 0.009 | P < .05 |
| Vc (L/kg) | 0.177 ± 0.021 | 0.154 ± 0.025 | N.S. |
| K12 (1/hr) | 1.788 ± 0.299 | 2.620 ± 0.502 | N.S. |
| K21 (1/hr) | 0.973 ± 0.094 | 1.038 ± 0.118 | N.S. |
Values show mean ± S.E. of six mice. Statistical significance is compared between two groups by Student’s ttest.