Comparison of the receptor binding profile of NAD-299 with that of WAY-100635
| Receptor | Affinity (Ki, nM) | |
|---|---|---|
| NAD-299 | WAY-100635 | |
| 5-HT1A | 0.59 ± 0.08 | 0.24 ± 0.01 |
| α1 | 260 ± 402-b | 45 ± 3 |
| α2 | >1000 | >1000 |
| β | 340 ± 50 | >1000 |
| D2A | >1000 | 79 ± 5 |
| D3 | >1000 | 67 ± 1 |
| r5-HTIB | >1000 | n.d. |
| 5-HT2A | >10000 | 1100 ± 150 |
| 5-HT6 | >39000 | n.d. |
| 5-HT7 | 1900 ± 160 | n.d. |
| 5-HT uptake | >10000 | n.d. |
| Muscarinic | >1000 | >1000 |
| Nicotinic | >10000 | >10000 |
| D1 | >1000 | >1000 |
| Histamine H1 | >10000 | >10000 |
| Histamine H2 | >10000 | >10000 |
| GABAA | >10000 | >10000 |
| NMDA | >10000 | >10000 |
| AMPA | >10000 | >10000 |
| Benzodiazepine | >10000 | >10000 |
| Galanin | >2600 | >2600 |
The competition studies were performed and the Kivalues were calculated as described under “Materials and Methods.” The results are means ± S.E. of at least two independent experiments made in duplicate.2-a