Influence of l-ornithine-l-aspartate on urea cycle enzyme activities in CCl4-induced cirrhotic rat livers
| Enzyme | Specific Activity (mU/mg Protein)2-a | |
|---|---|---|
| Cirrhotic Controls | Cirrhotic +l-Orn-l-Asp | |
| Carbamoylphosphate synthetase I | 23.6 ± 3.4 | 30.7 ± 5.8b |
| Ornithine trans- arbamoylase | 1391 ± 374 | 1143 ± 321 |
| Argininosuccinate synthetase | 4.2 ± 1.2 | 5.7 ± 1.1 |
| Argininosuccinate lyase | 21.9 ± 5.1 | 22.3 ± 3.7 |
| Arginase | 6685 ± 1540 | 9521 ± 3745c |
↵2-a Values represent means ± S.D. from six animals in each group determined after 14 days of QA treatment.
b,c Statistical significance. Different from respective controls: b P < .03; c P < .04.