Inhibitor | K562 | K562/ADM |
---|---|---|
(μl/1.0 × 106 cells) | ||
Control | 7.85 ± 0.683 | 2.38 ± 0.247 |
1 μM Cyclosporin A | 7.02 ± 0.828 | 4.78 ± 0.715* |
10 μM Cyclosporin A | 6.82 ± 0.329 | 6.74 ± 0.198* |
ATP-depleted | 9.14 ± 0.241 | 6.83 ± 0.339* |
Uptake of [14C]azasetron (4 μM) was measured at 37°C for 50 min in the presence or absence of cyclosporin A. ATP-depleted means the uptake of [14C]azasetron by cells that were ATP-depleted by treatment with NaF, NaN3 and 3-o-MG. Each datum represents the mean ± S.E. of three to six experiments.
* Significantly different from the control value by Student’st test (P < .05).