Effect of several compounds on [14C]azasetron uptake by Caco-2 cells
| Inhibitor | Concentration (mM) | Uptake Coefficient (μl/mg protein/min) |
|---|---|---|
| Control | 9.05 ± 0.950 | |
| Imipramine | 0.01 | 7.93 ± 0.455 |
| Imipramine | 5 | 5.64 ± 0.284* |
| Desipramine | 0.01 | 7.53 ± 0.925 |
| Desipramine | 5 | 4.63 ± 0.503* |
| Clomipramine | 5 | 7.31 ± 0.739 |
| Dopamine | 5 | 7.15 ± 0.729 |
| Serotonin | 0.01 | 6.32 ± 0.707 |
| Serotonin | 5 | 5.86 ± 0.287* |
| Choline | 5 | 7.48 ± 0.518 |
Uptake of [14C]azasetron (4 μM) was measured at 37°C for 1 min in the presence or absence of each inhibitor. Each datum represents the mean ± S.E. of three or four experiments.
* Significantly different from the control value by Student’st test (P < .05).