Table 4

MPTP/MPP⁺ kinetics in frontal cortex, hippocampus, and cerebellum at seven different time intervals

	Frontal Cortex		Hippocampus		Cerebellum
	MPTP	DSP-4 + MPTP	MPTP	DSP-4 + MPTP	MPTP	DSP-4 + MPTP
10 min
MPTP	206.2 ± 13.9	228.4 ± 17.2	138.9 ± 11.4	113.1 ± 8.7	131.8 ± 11.9	121.4 ± 13.1
MPP⁺	3.2 ± 0.4	3.5 ± 0.1	23.3 ± 2.6	23.1 ± 1.7	8.9 ± 1.6	7.1 ± 1.6
30 min
MPTP	/	68.1 ± 5.2^4-a	/	81.4 ± 9.1^4-a	/	84.2 ± 9.8^4-a
MPP⁺	42.2 ± 4.9	14.7 ± 2.6^4-a	37.6 ± 2.9	16.8 ± 1.9^4-a	36.8 ± 5.9	35.5 ± 4.7
1 h
MPTP	/	26.3 ± 8.5^4-a	/	/	/	/
MPP⁺	2.6 ± 2.0	16.8 ± 2.4^4-a	29.5 ± 3.8	34.5 ± 4.1	24.4 ± 2.7	12.6 ± 3.4^4-a
2 h
MPP⁺	76.2 ± 6.3	140.6 ± 11.7^4-a	38.4 ± 3.5	36.1 ± 2.0	4.4 ± 0.2	5.8 ± 0.6
4 h
MPP⁺	23.2 ± 3.4	57.8 ± 3.7^4-a	/	32.4 ± 2.7^4-a	/	/
6 h
MPP⁺	/	55.2 ± 4.6^4-a	/	17.8 ± 1.2^4-a	/	/
12 h
MPP⁺	/	/	/	/	/	/

MPTP and MPP⁺ levels at seven different time intervals after the administration of MPTP (30 mg/kg). Three days before MPTP administration, mice were injected with either saline or DSP-4 (50 mg/kg) to produce a selective lesion of NE terminals arising from the LC. Results are obtained from 10 animals sacrificed at each time interval from each group and are expressed as the mean ± S.E.M. Differences among groups were evaluated using ANOVA with Sheffé’s test.

↵4-a P < .05 compared with MPTP.