Daily injections of paroxetine do not alter the density of 5-HT1A receptors in any brain region
| Brain Region | Nuclei | Density of 3H-8-OH-DPAT-labeled 5-HT1A Receptors | ||||
|---|---|---|---|---|---|---|
| Saline | 1 day | 3 days | 7 days | 14 days | ||
| Cortex | ||||||
| Fr2 | layer 1–3 | 26.5 ± 1.5 | 22.9 ± 1.7 | 23.2 ± 1.6 | 23.3 ± 1.1 | 22.9 ± 2.2 |
| layer 5 | 72.6 ± 3.6 | 64.1 ± 2.6 | 64.6 ± 3.4 | 62.1 ± 3.2 | 64.2 ± 3.9 | |
| layer 6 | 63.1 ± 2.6 | 56.0 ± 2.5 | 57.4 ± 4.6 | 57.0 ± 2.3 | 56.3 ± 4.1 | |
| CG3 | layer 1–3 | 44.9 ± 4.4 | 40.3 ± 2.2 | 41.4 ± 4.3 | 40.4 ± 3.3 | 37.8 ± 3.8 |
| layer 5 | 65.5 ± 5.6 | 54.9 ± 3.5 | 56.7 ± 4.4 | 57.9 ± 4.3 | 56.3 ± 5.1 | |
| layer 6 | 62.5 ± 4.5 | 51.6 ± 1.8 | 52.1 ± 3.3 | 55.0 ± 3.8 | 54.8 ± 4.6 | |
| Hypothalamus | PVNm | 7.0 ± 0.6 | 5.8 ± 0.4 | 5.6 ± 0.3 | 6.1 ± 0.7 | 6.6 ± 0.7 |
| PVNp | 8.3 ± 0.7 | 7.3 ± 0.4 | 7.2 ± 0.4 | 8.0 ± 0.7 | 8.6 ± 0.6 | |
| AHN | 12.8 ± 0.6 | 10.8 ± 0.5 | 10.6 ± 1.0 | 10.9 ± 1.2 | 12.3 ± 0.8 | |
| LH | 4.7 ± 0.3 | 4.2 ± 0.3 | 4.2 ± 0.4 | 4.3 ± 0.2 | 4.7 ± 0.2 | |
| VMNdm | 21.6 ± 1.6 | 21.8 ± 1.4 | 21.2 ± 1.1 | 19.4 ± 1.0 | 18.9 ± 1.0 | |
| VMHc | 32.8 ± 2.6 | 32.2 ± 2.4 | 31.2 ± 2.1 | 27.8 ± 1.9 | 29.1 ± 1.8 | |
| VMHvl | 19.8 ± 1.3 | 19.2 ± 0.9 | 19.2 ± 1.1 | 17.7 ± 1.0 | 17.1 ± 0.8 | |
| DMH | 10.0 ± 0.9 | 9.8 ± 0.7 | 10.0 ± 0.4 | 8.6 ± 0.3 | 9.1 ± 0.3 | |
| Amygdala | AMce | 6.1 ± 0.4 | 6.5 ± 0.5 | 6.4 ± 0.2 | 6.1 ± 0.3 | 5.4 ± 0.3 |
| AMlp | 11.5 ± 0.7 | 11.1 ± 0.7 | 13.1 ± 0.4 | 11.8 ± 0.7 | 11.2 ± 0.4 | |
| AMbl | 17.2 ± 1.1 | 16.7 ± 0.8 | 17.3 ± 0.7 | 17.2 ± 0.7 | 16.8 ± 0.6 | |
| AMbm | 26.5 ± 2.1 | 24.3 ± 2.2 | 24.5 ± 1.7 | 23.0 ± 1.1 | 24.1 ± 1.3 | |
| AMm | 18.7 ± 2.1 | 18.1 ± 1.0 | 18.6 ± 0.7 | 18.0 ± 0.9 | 17.8 ± 0.6 | |
| Hippocampus | CA1 | 62.9 ± 1.7 | 49.1 ± 5.8 | 51.9 ± 3.0 | 43.9 ± 4.7 | 59.0 ± 4.0 |
| CA2 | 14.5 ± 0.4 | 12.2 ± 1.3 | 11.6 ± 0.5 | 10.6 ± 0.9 | 13.6 ± 0.8 | |
| CA3 | 31.6 ± 1.1 | 26.5 ± 3.2 | 27.3 ± 2.0 | 25.2 ± 3.2 | 31.9 ± 2.3 | |
| DG | 84.1 ± 3.0 | 66.5 ± 5.5 | 70.7 ± 4.4 | 63.2 ± 6.4 | 78.3 ± 5.2 | |
| Midbrain | DR | 30.8 ± 1.8 | 32.4 ± 1.5 | 32.0 ± 0.9 | 32.9 ± 0.4 | 31.9 ± 0.9 |
| MR | 21.7 ± 1.7 | 23.4 ± 2.2 | 20.5 ± 1.2 | 20.2 ± 1.4 | 18.5 ± 0.9 | |
The data represent mean ± S.E.M. (fmol3H-8-OH-DPAT/mg tissue equivalent) of 5 to 6 rats per group.
Abbreviations: AHN: Anterior hypothalamic nucleus; AMbl: Basolateral amygdaloid nucleus; AMbm: Basomedial amygdaloid nucleus; AMce: Central amygdaloid nucleus; AMlp: Lateral amygdaloid nucleus, posterior region; AMm: Medial amygdaloid nucleus; CA1–3: Field CA1, CA2 and CA3 of ammon’s horn in the hippocampus; CG3: Cingulate cortex, area 3; DG: Dentate gyrus (hippocampus); DMH: Dorsomedial hypothalamic nucleus; DR: Dorsal raphe nucleus; Fr2: Frontal cortex, area 2; LH: Lateral hypothalamic area; MR: Median raphe nucleus; PVNm: Paraventricular hypothalamic nucleus, magnocellular region; PVNp: Paraventricular hypothalamic nucleus, parvocellular region; VMHc: Ventromedial hypothalamic nucleus, central region; VMHdm: Ventromedial hypothalamic nucleus, dorsomedial region; VMHvl: Ventromedial hypothalamic nucleus, ventrolateral region.