Calculation of the organ parameters for NOAC according to Nishikawaet al. (1993) and comparison to ara-C
| Parameters3-a | NOAC | ara-C3-b | ||
|---|---|---|---|---|
| Dose (mg/g)3-c | 70 ± 10 | 1 | ||
| AUC(0→120 min)(%h/ml) | 113-d | 3.13-e | ||
| μl/h | %3-f | μl/h | % | |
| Cltotal | 4,400 | 100 | 28,900 | 100 |
| Clliver | 2,430 | 55 | 357 | 1.2 |
| Clspleen | 38 | 1 | n.a.3-g | |
| Clkidneys | 214 | 5 | n.a.3-g | |
| Clurine | 1,4463-h | 33 | 23,000 | 80 |
| Cllung | 76 | 2 | n.a.3-g | |
| Clbrain | 5 | 0.1 | n.a.3-g | |
↵3-a Data calculated for mice with a 26.5-g average body weight to compare values with Nishikawa et al. (1993) in which mice of 25–28 g were used.
↵3-b Data from Nishikawa et al. (1993).
↵3-c Dose per gram body weight.
↵3-d AUC(0→120 min) calculated from blood concentrationversus time curve.
↵3-e AUC(0→120 min) calculated from plasma concentrationversus time curve.
↵3-f Percent of the total clearance Cltotal.
↵3-g n.a., not analyzed.
↵3-h Calculated from the preliminary data of cumulative drug excretion in the urine of mice kept in metabolic cages for 48 h and determined by use of the slope of the excretion rate of the sampling period versus the blood concentration of NOAC.