Organ | Peak Concentrations | Organ Load2-a | Elimination half-timet1/2β | |
---|---|---|---|---|
%2-b | min2-c | % | h | |
Blood | 14.1 ± 0.6 | 4 | 10.8 | 6.9 |
Liver | 24.4 ± 2.1 | 30 | 68.8 | 7.9 |
Spleen | 0.5 ± 0.1 | 30 | 1.5 | 7.8 |
Kidneys | 1.8 ± 0.1 | 180 | 14.7 | 16 |
Lung | 0.9 ± 0.1 | 4 | 4.2 | 11 |
Brain | 0.06 ± 0.02 | 4 | n.d.2-d | n.d.2-d |
↵2-a Organ AUC(tr. 0→∞) calculated as percent of the sum of all organ AUC(tr. 0→∞) values.
↵2-b Percentage of injected dose in total organ as means of triplicates ± S.D., standardized for mice of 20 g body weight (figs. 5 and 6).
↵2-c Time of the observed relative peak concentration.
↵2-d n.d., not determined.