Organ permeability-surface area (PS) products at 60 min after injection of daunomycin, liposomes and immunoliposomes
| PS Product (μl/Min/g Tissue)2-a | |||||
|---|---|---|---|---|---|
| Heart | Kidney | Lung | Liver | Spleen | |
| Daunomycin | 163.1 ± 11.2 | 278.6 ± 5.9 | 419.3 ± 47.6 | 191.9 ± 13.7 | 329.1 ± 72.8 |
| Liposomes | 8.6 ± 1.7 | 15.8 ± 6.0 | 23.1 ± 5.0 | 73.6 ± 13.2 | 217.8 ± 79.7 |
| PEG-liposomes | 0.00 ± 0.05 | 0.00 ± 0.09 | 0.00 ± 0.30 | 0.00 ± 0.12 | 0.00 ± 1.07 |
| IgG2a | 0.8 ± 0.2 | 2.4 ± 0.2 | 1.5 ± 0.9 | 1.4 ± 0.12 | 2.3 ± 0.52 |
| OX2629 | 3.7 ± 0.3 | 10.4 ± 2.0 | 8.3 ± 0.6 | 6.1 ± 0.4 | 17.4 ± 2.0 |
| OX26197 | 2.3 ± 0.1 | 5.8 ± 0.2 | 9.2 ± 2.0 | 8.8 ± 0.6 | 46.8 ± 9.8 |
| OX26197 + 1 mg OX26 | 0.7 ± 0.7 | 6.5 ± 2.7 | 3.5 ± 1.1 | 5.2 ± 1.3 | 5.2 ± 2.1 |
↵2-a Values represent means ± S.E.M. ofn = 3 experiments.