Table 1

Daunomycin area under the plasma concentration curve (AUC) determined at 60 min after injection of free drug or drug incorporated in liposomes and immunoliposomes

Daunomycin Vehicle	Vehicle^1-a		AUC₀^60 min	AUC₀^∞
Daunomycin Vehicle	Lipo	PEG	IgG	(%ID ∗ min/ml)^1-b	(%ID ∗ min/ml)^1-b
Free drug	−	−	−	5.5 ± 0.9	6.6 ± 0.9
Liposomes	+	−	−	34.9 ± 10.9	42.9 ± 14.3
PEG-liposomes	+	+	−	557.1 ± 46.7	1880.9 ± 26.0
IgG_2a	+	+	+	347.3 ± 27.9	795.8 ± 134.9
OX26₂₉	+	+	+	196.4 ± 19.3	316.7 ± 34.9
OX26₁₉₇	+	+	+	196.2 ± 5.1	401.4 ± 21.7
OX26₁₉₇ + 1 mg OX₂₆	+	+	+	460.5 ± 27.8	1228.5 ± 132.7

↵1-a Lipo, liposomes; PEG, polyethylene glycol of MW 2000; IgG, OX26 or mouse IgG_2a isotype control.
↵1-b Values represent means ± S.E.M. of n = 3 experiments.