Table 3

Effects of coadministered drugs on in vitro N-hydroxylation of riluzole by human hepatic microsomes

DrugInhibition3-aIC50
% μM
Clomipramine99265  ± 25
Diclofenac99234  ± 19
Amitriptyline94210  ± 17
Imipramine85356  ± 20
Enoxacin71465  ± 77
Nicergoline71256  ± 13
Quinine63444  ± 62
Diazepam59240  ± 23
Theophylline47
Cimetidine40937  ± 182
Caffeine37
Ranitidine29
Paracetamol28
Pyridoxine18
Enalapril12
  • 3-a Inhibition measured at a riluzole concentration of 15 μM and an inhibitor concentration of 1 mM for all drugs except nicergoline and diazepam (both 0.5 mM).