Table 2

IC50 values and Hill coefficients for Pb2+ inhibition of Glu-activated currents

Injected cRNAGlutamatePb2+ IC50
μM μM; Hill coefficient; n
NR1b-2A10002-a 1.52  ± 0.66
(0.71 ± 0.09)
6
NR1b-2C102-a 3.71  ± 0.46
(0.92 ± 0.04)
5
NR1b-2D1002-a 4.86  ± 0.79
(1.62 ± 0.25)
10
NR1b-2AC3002-a 8.19  ± 1.85
(1.10 ± 0.10)
8
33.39  ± 1.152-b
(0.90 ± 0.11)
6

  • All values are given as the mean ± S.E.M.

  • ↵2-a Saturating Glu concentration.

  • ↵2-b Significant difference from NR1b-2AC at a saturating Glu concentration (analysis of variance, P < 0.003).