Effect of allopregnanolone on percentage of recording time spent in different vigilance states
| State | Hours | Vehicle | Allopregnanolone | |
|---|---|---|---|---|
| 7.5 mg/kg | 15 mg/kg | |||
| Wakefulness | 1–6 | 29.7 ± 6.3 | 25.7 ± 2.8 | 27.3 ± 4.0 |
| 1–2 | 37.5 ± 10.2 | 27.6 ± 5.9 | 27.0 ± 9.5 | |
| 3–4 | 24.7 ± 10.1 | 27.3 ± 5.8 | 30.0 ± 6.0 | |
| 5–6 | 26.8 ± 13.3 | 22.1 ± 6.5 | 24.9 ± 12.4 | |
| Non-REMS | 1–6 | 56.5 ± 6.0 | 59.4 ± 4.3 | 57.8 ± 6.4 |
| 1–2 | 55.6 ± 10.5 | 63.0 ± 5.4 | 62.2 ± 8.3 | |
| 3–4 | 59.4 ± 6.6 | 57.7 ± 7.6 | 54.0 ± 4.1 | |
| 5–6 | 54.5 ± 10.7 | 57.5 ± 7.2 | 57.0 ± 12.7 | |
| Pre-REMS | 1–6 | 3.5 ± 1.6 | 4.2 ± 1.32-a | 5.2 ± 1.82-b |
| 1–2 | 2.5 ± 1.6 | 3.6 ± 1.7 | 5.8 ± 3.22-b | |
| 3–4 | 4.0 ± 1.2 | 4.3 ± 1.6 | 4.9 ± 2.6 | |
| 5–6 | 4.1 ± 2.6 | 4.7 ± 1.2 | 4.9 ± 1.2 | |
| REMS | 1–6 | 10.3 ± 2.3 | 10.7 ± 3.1 | 9.8 ± 2.3 |
| 1–2 | 4.5 ± 1.6 | 5.9 ± 3.2 | 5.0 ± 2.4 | |
| 3–4 | 11.9 ± 5.2 | 10.6 ± 3.8 | 11.1 ± 3.4 | |
| 5–6 | 14.6 ± 3.3 | 15.7 ± 3.5 | 13.2 ± 2.7 | |