Comparison of pK B values for TP receptor antagonists
| Agonist | TP receptor antagonists | ||
|---|---|---|---|
| SQ29548 | L670596 | GR32191 | |
| U46619 | 8.21 ± 0.14 | 8.93 ± 0.092-a | 8.44 ± 0.15 |
| 8-Iso-PGE2 | 8.21 ± 0.25 | 8.66 ± 0.06 | 8.45 ± 0.10 |
| 8-Iso-PGF2α | 8.21 ± 0.07 | 8.62 ± 0.02 | 8.46 ± 0.07 |
↵2-a Significant difference in pK Bvalues between agonists (ANOVA with post hoc Newman-Keuls analysis, P < .05). It should be noted that pK B values are unique to a particular antagonist and therefore comparisons made between different antagonists are not relevant.
Values are mean ± S.E.M. of 4 experiments performed in triplicate.